Endocrine Abstracts

Background: Follicles imaturation, as the hallmark of polycystic ovarian syndrome caused by prenatal androgen exposure, is suspected to be effected through expression changes of related genes. The aim of this study was to evaluate gene expression and promoter methylation of GATA6 and Follistatin (FST), two factors involved in follicle maturation, in adult female rats prenatally exposed to androgen excess by comparing them with non-treated rats.Material a...

Objective: The aim of this study was the assessment of association of two single nucleotide polymorphism (SNP) of thyroid peroxidase (TPO) gene with anti TPO antibody titer for the first time.Materials and methods: In this case–control study, peripheral blood samples of 428 individuals, 178 men (29–76 y) and 250 women (21–76 y) from unrelated families were genotyped (G1201T of exon 8 and A2257C of exon 12) by PCR amplification and RLFP met...